Yes! The chemical Picloram is a persistent herbicide used to control broadleaf plants, brush, conifers and broadleaf trees. It is used to control weeds for agricultural and industrial applications including pasture, rangeland, railroads and power lines. Picloram is extremely phytotoxic (toxic to plants). It poses a significant risk to non-target plants. Estimated concentrations of Picloram in the environment are hundreds to thousands of times the ‘level of concern’ at which 25% of seedlings fail to emerge. As little as 1 part-per-billion in water was found to be enough to permanently damage plants. Animals exposed to toxicity studies showed changes in the liver, decrease in body weight gain, food consumption, liver enzyme changes, skin irritation, redness and swelling. In developmental studies, some signs of maternal toxicity were observed. Picloram is toxic to legumes and some nitrogen fixing grasses. Natural soil building processes may be halted by Picloram. See our Common Problems page on Picloram.